Infant mortality and morbidity associated with preterm and small-for-gestational-age births in Southern Mozambique: A retrospective cohort studyReport as inadecuate




Infant mortality and morbidity associated with preterm and small-for-gestational-age births in Southern Mozambique: A retrospective cohort study - Download this document for free, or read online. Document in PDF available to download.

Background

Preterm and small for gestational age SGA births have been associated with adverse outcomes during the first stages of life. We evaluated the morbidity and mortality associated with preterm and SGA births during the first year of life in a rural area of Southern Mozambique.

Methods

This is a retrospective cohort study using previously collected data from children born at the Manhiça District Hospital in two different periods 2003–2005 and 2010–2012. Newborns were classified as being preterm and-or SGA or as babies not fulfilling any of the previous conditions term non-SGA. All children were followed up for a year for morbidity and mortality outcomes.

Results

A total of 5574 live babies were included in the analysis. The prevalence of preterm delivery was 6.2% 345-5574; the prevalence of SGA was 14.0% 776-5542 and 2.2% 114-5542 of the children presented both conditions. During the neonatal period, preterm delivery and SGA were associated with 13 HR: 13.0, 95% CI 4.0–42.2 and 5 times HR: 4.5, 95% CI: 1.6–12.6 higher mortality compared to term non SGA babies. Risk of hospitalization was only increased when both conditions were present IRR: 3.5, 95%CI: 1.5–8.1. Mortality is also increased during the entire first year, although at a lower rate.

Conclusions

Neonatal and infant mortality rates are remarkably high among preterm and SGA babies in southern Mozambique. These increased rates are concentrated within the neonatal period. Prompt identification of these conditions is needed to implement interventions aimed at increasing survival of these high-risk newborns.



Author: Alberto L. García-Basteiro , Llorenç Quintó, Eusebio Macete, Azucena Bardají, Raquel González, Arsenio Nhacolo, Betuel Sigau

Source: http://plos.srce.hr/



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