Reproducibility and comparison of oxygen-enhanced T1 quantification in COPD and asthma patientsReport as inadecuate

Reproducibility and comparison of oxygen-enhanced T1 quantification in COPD and asthma patients - Download this document for free, or read online. Document in PDF available to download.

T1 maps have been shown to yield useful diagnostic information on lung function in patients with chronic obstructive pulmonary disease COPD and asthma, both for native T1 and ΔT1, the relative reduction while breathing pure oxygen. As parameter quantification is particularly interesting for longitudinal studies, the purpose of this work was both to examine the reproducibility of lung T1 mapping and to compare T1 found in COPD and asthma patients using IRSnapShotFLASH embedded in a full MRI protocol. 12 asthma and 12 COPD patients site 1 and further 15 COPD patients site 2 were examined on two consecutive days. In each patient, T1 maps were acquired in 8 single breath-hold slices, breathing first room air, then pure oxygen. Maps were partitioned into 12 regions each to calculate average values. In asthma patients, the average T1,RA = 1206ms room air was reduced to T1,O2 = 1141ms under oxygen conditions ΔT1 = 5.3%, p < 5⋅10−4, while in COPD patients both native T1,RA = 1125ms was significantly shorter p < 10−3 and the relative reduction to T1,O2 = 1081ms on average ΔT1 = 4.2%p < 10−5. On the second day, with T1,RA = 1186ms in asthma and T1,RA = 1097ms in COPD, observed values were slightly shorter on average in all patient groups. ΔT1 reduction was the least repeatable parameter and varied from day to day by up to 23% in individual asthma and 30% in COPD patients. While for both patient groups T1 was below the values reported for healthy subjects, the T1 and ΔT1 found in asthmatics lies between that of the COPD group and reported values for healthy subjects, suggesting a higher blood volume fraction and better ventilation. However, it could be demonstrated that lung T1 quantification is subject to notable inter-examination variability, which here can be attributed both to remaining contrast agent from the previous day and the increased dependency of lung T1 on perfusion and thus current lung state.

Author: Simon M. F. Triphan , Bertram J. Jobst, Angela Anjorin, Oliver Sedlaczek, Ursula Wolf, Maxim Terekhov, Christian Hoffmann, Sebast



Related documents