Effect of women’s age on embryo morphology, cleavage rate and competence—A multicenter cohort studyReport as inadecuate




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This multicenter cohort study on embryo assessment and outcome data from 11,744 IVF-ICSI cycles with 104,830 oocytes and 42,074 embryos, presents the effect of women’s age on oocyte, zygote, embryo morphology and cleavage parameters, as well as cycle outcome measures corrected for confounding factors as center, partner’s age and referral diagnosis. Cycle outcome data confirmed the well-known effect of women’s age. Oocyte nuclear maturation and proportion of 2 pro-nuclear 2PN zygotes were not affected by age, while a significant increase in 3PN zygotes was observed in both IVF and ICSI p<0.0001 with increasing age. Maternal age had no effect on cleavage parameters or on the morphology of the embryo day 2 post insemination. Interestingly, initial hCG value after single embryo transfer followed by ongoing pregnancy was increased with age in both IVF p = 0.007 and ICSI p = 0.001 cycles. For the first time, we show that a woman’s age does impose a significant footprint on early embryo morphological development 3PN. In addition, the developmentally competent embryos were associated with increased initial hCG values as the age of the women increased. Further studies are needed to elucidate, if this increase in initial hCG value with advancing maternal age is connected to the embryo or the uterus.



Author: Marie Louise Grøndahl , Sofie Lindgren Christiansen, Ulrik Schiøler Kesmodel, Inge Errebo Agerholm, Josephine Gabriela Lemmen,

Source: http://plos.srce.hr/



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