The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysisReport as inadecuate




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Background

The interaction between genetic and environmental factors is crucial to multiple sclerosis MS pathogenesis. Human Endogenous Retroviruses HERVs are endogenous viral elements of the human genome whose expression is associated with MS.

Objective

To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients.

Methods

Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS. Meta-analysis was performed on the HERV-W family. Odds Ratio OR and 95% confidence interval CI were calculated for association.

Results

43 reports were extracted 25 related to HERV-W, 13 to HERV-H, 9 to HERV-K, 5 to HRES-1 and 1 to HER-15 family. The analysis showed an association between expression of all HERV families and MS. For HERV-W, adequate data was available for meta-analysis. Results from meta-analyses of HERV-W were OR = 22.66 95%CI 6.32 to 81.20 from 4 studies investigating MSRV-HERV-W MS-associated retrovirus envelope mRNA in peripheral blood mononuclear cells, OR = 44.11 95%CI 12.95 to 150.30 from 6 studies of MSRV-HERV-W polymerase mRNA in serum-plasma and OR = 6.00 95%CI 3.35 to 10.74 from 4 studies of MSRV-HERV-W polymerase mRNA in CSF.

Conclusions

This systematic review and meta-analysis shows an association between expression of HERVs, and in particular the HERV-W family, and MS.



Author: Elena Morandi, Radu Tanasescu, Rachael E. Tarlinton, Cris S. Constantinescu, Weiya Zhang, Christopher Tench, Bruno Gran

Source: http://plos.srce.hr/



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