COMT and DRD2-ANKK-1 gene-gene interaction account for resetting of gamma neural oscillations to auditory stimulus-driven attentionReport as inadecuate




COMT and DRD2-ANKK-1 gene-gene interaction account for resetting of gamma neural oscillations to auditory stimulus-driven attention - Download this document for free, or read online. Document in PDF available to download.

Attention capture by potentially relevant environmental stimuli is critical for human survival, yet it varies considerably among individuals. A large series of studies has suggested that attention capture may depend on the cognitive balance between maintenance and manipulation of mental representations and the flexible switch between goal-directed representations and potentially relevant stimuli outside the focus of attention; a balance that seems modulated by a prefrontostriatal dopamine pathway. Here, we examined inter-individual differences in the cognitive control of attention through studying the effects of two single nucleotide polymorphisms regulating dopamine at the prefrontal cortex and the striatum i.e., COMTMet108-158Val and ANKK1-DRD2TaqIA on stimulus-driven attention capture. Healthy adult participants N = 40 were assigned to different groups according to the combination of the polymorphisms COMTMet108-158Val and ANKK1-DRD2TaqIA, and were instructed to perform on a well-established distraction protocol. Performance in individuals with a balance between prefrontal dopamine display and striatal receptor density was slowed down by the occurrence of unexpected distracting events, while those with a rather unbalanced dopamine activity were able maintain task performance with no time delay, yet at the expense of a slightly lower accuracy. This advantage, associated to their distinct genetic profiles, was paralleled by an electrophysiological mechanism of phase-resetting of gamma neural oscillation to the novel, distracting events. Taken together, the current results suggest that the epistatic interaction between COMTVal108-158Met and ANKK1-DRD2 TaqIa genetic polymorphisms lies at the basis of stimulus-driven attention capture.



Author: Manuel Garcia-Garcia, Marc Via, Katarzyna Zarnowiec, Iria SanMiguel, Carles Escera , Immaculada C. Clemente

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents