Circulating C1q complement-TNF-related protein CTRP 1, CTRP9, CTRP12 and CTRP13 concentrations in Type 2 diabetes mellitus: In vivo regulation by glucoseReport as inadecuate




Circulating C1q complement-TNF-related protein CTRP 1, CTRP9, CTRP12 and CTRP13 concentrations in Type 2 diabetes mellitus: In vivo regulation by glucose - Download this document for free, or read online. Document in PDF available to download.

Objectives

The C1q complement-TNF-related protein CTRP superfamily, which includes the adipokine adiponectin, has been shown in animal models to have positive metabolic and cardiovascular effects. We sought to investigate circulating CTRP1, CTRP9, CTRP12 and CTRP13 concentrations in persons with type 2 diabetes mellitus T2DM, with age and BMI matched controls, and to examine the effects of a 2 hour 75g oral glucose tolerance test OGTT on serum CTRP1, CTRP9, CTRP12 and CTRP13 levels in persons with T2DM.

Design

Cross-sectional study newly diagnosed T2DM n = 124 and control n = 139 participants. Serum CTRP1, CTRP9, CTRP12 and CTRP13 were measured by ELISA.

Results

Systolic and diastolic blood pressure, total cholesterol TCH, Low-density lipoprotein LDL-cholesterol, triglycerides, TCH-High-density lipoprotein HDL ratio, triglycerides-HDL ratio, glucose, insulin, homeostatic model assessment–insulin resistance HOMA-IR, C-reactive protein and endothelial lipase were significantly higher, whereas leptin and adiponectin were significantly lower in T2DM participants. Serum CTRP1 were significantly higher and CTRP12 significantly lower in T2DM participants. Age, diastolic blood pressure, glucose and CTRP12 were predictive of serum CTRP1; leptin was predictive of serum CTRP9; glucose and CTRP1 were predictive of serum CTRP12; endothelial lipase was predictive of serum CTRP13. Finally, serum CTRP1 were significantly higher and CTRP12 significantly lower in T2DM participants after a 2 hour 75g OGTT.

Conclusions

Our data supports CTRP1 and CTRP12 as potential novel biomarkers for the prediction and early diagnosis of T2DM. Furthermore, pharmacological agents that target CTRP1 and CTRP12 could represent a new strategy in the treatment of T2DM.



Author: Bo Bai , Bo Ban , Zunjing Liu , Man Man Zhang, Bee Kang Tan , Jing Chen

Source: http://plos.srce.hr/



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