Mediterranean dietary pattern and VEGF 405 G-C gene polymorphisms in patients with metabolic syndrome: An aspect of gene-nutrient interactionReportar como inadecuado




Mediterranean dietary pattern and VEGF 405 G-C gene polymorphisms in patients with metabolic syndrome: An aspect of gene-nutrient interaction - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Aims

To evaluate the relationship between Mediterranean dietary pattern, anthropometric and metabolic biomarkers and vascular endothelial growth factor VEGF +405 G-C gene polymorphism in patient with metabolic syndrome Mets.

Materials and methods

In this study 150 patients with Mets and 50 healthy subjects were enrolled. Dietary intakes were evaluated with a semi-quantitative food-frequency questionnaire FFQ and Mediterranean dietary quality index Med-DQI was assessed. Anthropometric assessments and blood pressure measurement were performed. Biochemical assays including fasting serum glucose FSG, matrix metalloproteinase-3 MMP-3, liver enzymes and lipid profiles were also assessed. Polymorphism of +405 G-C VEGF gene was determined utilizing polymerase chain reaction-restriction fragments length polymorphism PCR-RFLP method.

Results

Serum high density lipoprotein-cholesterol HDL-C was significantly lower and low density lipoprotein cholesterol LDL-C, triglyceride TG, total cholesterol TC concentrations and FSG were significantly higher in metabolic syndrome patients compared with control group P < 0.05. Metabolic syndrome group with high consumption of -cholesterol- had significantly upper serum TG; also high consumption of -fish- and -vegetables-fruits- was associated with a significantly lower serum LDL concentrations. In metabolic syndrome patients with CC genotype, mean score of -saturated fatty acid- subgroup was significantly higher compared with other genotypes; whereas, in healthy individuals, mean score of -fruit-vegetable- subgroup in individuals of CC and GG genotype was significantly higher P<0.05.

Conclusion

Our findings indicated a significant relationship between Mediterranean dietary quality index and both anthropometric and metabolic risk factors. We also indicated a higher -saturated fatty acid- intake in CC genotype among metabolic syndrome patients.



Autor: Ghazaleh Hajiluian, Mahdieh Abbasalizad Farhangi , Leila Jahangiry

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados