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Case Reports in Gastrointestinal Medicine - Volume 2015 2015, Article ID 685459, 2 pages -

Case Report

Department of Medical Oncology, Ankara University School of Medicine, 06300 Ankara, Turkey

Department of Internal Medicine, Ankara University School of Medicine, 06300 Ankara, Turkey

Received 12 October 2014; Accepted 14 February 2015

Academic Editor: Haruhiko Sugimura

Copyright © 2015 Dilsa Mizrak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Osteogenesis imperfecta OI is a rare, inherited skeletal disorder characterized by abnormalities of type 1 collagen. Malignancy is rarely reported in patients with OI and it was suggested that this disease can protect against cancer. Here, we report a 41-year-old woman with symptoms of achalasia where repeated treatment of pneumatic dilation and stent replacement was unsuccessful; therefore, surgery was performed. Pathology showed gastric adenocarcinoma unexpectedly. Chemotherapy was given after assessing dihydropyrimidine dehydrogenase DPD enzyme activity, which can be deficient in OI patients. This is the first report of gastric cancer mimicking achalasia in a patient with OI.

Autor: Dilsa Mizrak, Ali Alkan, Batuhan Erdogdu, and Gungor Utkan

Fuente: https://www.hindawi.com/


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