Risk of dementia from proton pump inhibitor use in Asian population: A nationwide cohort study in TaiwanReportar como inadecuado




Risk of dementia from proton pump inhibitor use in Asian population: A nationwide cohort study in Taiwan - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Introduction

Concerns have been raised regarding the potential association between proton pump inhibitor PPI use and dementia.

Objective

This study aimed to examine this association in an Asian population.

Methods

Patients initiating PPI therapy between January 1, 2000 and December 31, 2003 without a prior history of dementia were identified from Taiwan’s National Health Insurance Research Database. The outcome of interest was all-cause dementia. Cox regression models were applied to estimate the hazard ratio HR of dementia. The cumulative PPI dosage stratified by quartiles of defined daily doses and adjusted for baseline disease risk score served as the primary variables compared against no PPI use.

Results

We analyzed the data of 15726 participants aged 40 years or older and free of dementia at baseline. PPI users n = 7863; average follow-up 8.44 years had a significantly increased risk of dementia over non—PPI users n = 7863; average follow-up 9.55 years adjusted HR aHR 1.22; 95% confidence interval: 1.05–1.42. A significant association was observed between cumulative PPI use and risk of dementia P for trend = .013. Subgroup analysis showed excess frequency of dementia in PPI users diagnosed with depression aHR 2.73 1.91–3.89, hyperlipidemia aHR 1.81 1.38–2.38, ischemic heart disease aHR 1.55 1.12–2.14, and hypertension aHR 1.54 1.21–1.95.

Conclusions

An increased risk for dementia was identified among the Asian PPI users. Cumulative PPI use was significantly associated with dementia. Further investigation into the possible biological mechanisms underlying the relationship between dementia and PPI use is warranted.



Autor: Shu-Yu Tai, Chen-Yu Chien, Deng-Chyang Wu, Kun-Der Lin, Bo-Lin Ho, Yu-Han Chang, Yang-Pei Chang

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados