Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1-CD71Reportar como inadecuado




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International Journal of Endocrinology - Volume 2014 2014, Article ID 685396, 11 pages -

Review Article

Department of Bio-Medical Sciences, Physiology Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy

Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Via S. Sofia 87, 95123 Catania, Italy

Received 19 February 2014; Revised 15 May 2014; Accepted 17 June 2014; Published 1 July 2014

Academic Editor: Giuliana Salvatore

Copyright © 2014 Rosalba Parenti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Anaplastic thyroid carcinoma ATC is one of the most aggressive human cancers. Actually, ATC is refractory to conventional therapies, including surgery, chemotherapy, radiotherapy, and radioiodine

I therapy. Accordingly, genetic and molecular characterizations of ATC have been frequently and periodically reviewed in order to identify potential biological markers exploitable for target therapy. This review briefly focuses on main molecular events that characterize ATC and provides an update about preclinical studies. In addition, the overexpression of transferrin receptor 1 TfR1-CD71 by neoplastic cells of ATC is emphasized in that it could represent a potential therapeutic target. In this regard, new therapeutic approaches based on the use of monoclonal or recombinant antibodies, or transferrin-gallium-TfR1-CD71 molecular complexes, or lastly small interfering RNAs siRNAs are proposed.





Autor: Rosalba Parenti, Lucia Salvatorelli, and Gaetano Magro

Fuente: https://www.hindawi.com/



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