IMPACT-CABG Trial: Implantation of CD133 Stem Cells in Patients Undergoing Coronary Bypass Surgery—Presentation of the First Treated PatientReportar como inadecuado




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Case Reports in TransplantationVolume 2011 2011, Article ID 685394, 3 pages

Case Report

Department of Cardiac Surgery, CHUM, 3840 Rue Saint-Urbain, Montréal, QC, H2W 1T7, Canada

Surgery Department, Université de Montréal, Montréal, QC, H3C 3J7, Canada

CHUM Research Center CRCHUM, Montréal, QC, H2W 1T7, Canada

Cardiology Department, CHUM, Montréal, QC, H2W 1T7, Canada

Hematology Department, Maisonneuve-Rosemont Hospital, Montréal, QC, H1T 2M4, Canada

Received 13 April 2011; Accepted 29 April 2011

Academic Editors: D. Mandelbrot and G. McQuaker

Copyright © 2011 Jessica Forcillo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The IMPACT-CABG study is the first Canadian randomized-controlled phase II clinical trial aiming to assess the effect of intramyocardial IM injections of CD133

-selected stem cells in patients referred for coronary artery bypass graft CABG with a “chronic” myocardial infarction and persistent left ventricular dysfunction. Patients are followed for 2 years with different imaging techniques including the stress magnetic resonance to evaluate the global and regional myocardial viability. Before the beginning of the randomization, the 5 first patients are treated in an open-label fashion to assess safety and feasibility of the IM CD133

injections. Herein, we report the first Canadian patient treated with IM injection of CD133

cells during CABG surgery as part of the IMPACT-CABG trial.





Autor: Jessica Forcillo, Louis-Mathieu Stevens, Samer Mansour, Ignacio Prieto, Denis-Claude Roy, and Nicolas Noiseux

Fuente: https://www.hindawi.com/



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