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BioMed Research International - Volume 2016 2016, Article ID 3801026, 10 pages -

Review Article

Department of Microbiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China

State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, China

Received 14 January 2016; Revised 5 April 2016; Accepted 16 May 2016

Academic Editor: Kevin M. Coombs

Copyright © 2016 Zhen Qin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The risk of influenza A virus IAV is more likely caused by secondary bacterial infections. During the past decades, a great amount of studies have been conducted on increased morbidity from secondary bacterial infections following influenza and provide an increasing number of explanations for the mechanisms underlying the infections. In this paper, we first review the recent research progress that IAV infection increased susceptibility to bacterial infection. We then propose an assumption that autophagy and apoptosis manipulation are beneficial to antagonize post-IAV bacterial infection and discuss the clinical significance.

Autor: Zhen Qin, Yuan Yang, Hongren Wang, Jun Luo, Xiaojun Huang, Jiangzhou You, Baoning Wang, and Mingyuan Li



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