Subfoveal Choroidal Thickness in Central Serous Chorioretinopathy: A Meta-AnalysisReport as inadecuate

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To evaluate the relationship between subfoveal choroidal thickness SFCT and eyes with central serous chorioretinopathy CSC versus fellow or control eyes.


We performed a meta-analysis using databases including PubMed, Embase and ISI Web of Science to find relevant studies. Weighted mean difference WMD was calculated for the SFCT in CSC eyes, the unaffected fellow eyes and normal controls.


Twelve studies were selected for this meta-analysis, including 1108 eyes 397 CSC eyes, 228 unaffected fellow eyes and 483 eyes of normal controls. The meta-analysis clearly demonstrated that the subfoveal choiroid of eyes with a clinical presentation of CSC was thickened compared to unaffected fellow eyes WMD = 52.81, 95% confidence interval CI, 39.13–66.49, P<0.00001 and was thickened compared to control eyes WMD = 145.03, 95%CI, 121.33–168.73, P<0.00001. The mean SFCT measurement of the unaffected fellow eyes showed also significantly increased choroidal thickness compared to that of normal control eyes WMD = 77.20, 95% CI, 44.98–109.42, P<0.00001. Similar results were obtained in a sub-analysis based on the same instrument.


It is demonstrated that SFCT is significantly increased in eyes with clinical manifestation of CSC, and in the clinically non-manifested fellow eyes. These results support the hypothesis that CSC is a bilateral disorder with an initial unilateral clinical presentation.

Author: Guohai Chen , Radouil Tzekov , Wensheng Li , Fangzheng Jiang, Sihong Mao, Yuhua Tong



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