Genetic Variants in MTHFR Gene Predict ≥ 2 Radiation Pneumonitis in Esophageal Squamous Cell Carcinoma Patients Treated with Thoracic RadiotherapyReportar como inadecuado




Genetic Variants in MTHFR Gene Predict ≥ 2 Radiation Pneumonitis in Esophageal Squamous Cell Carcinoma Patients Treated with Thoracic Radiotherapy - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Reactive oxygen species ROS, formed as an indirect production of radiotherapy RT, could cause DNA damage of normal tissues. Meanwhile, our body possesses the ability to restore the damage by DNA repair pathways. The imbalance between the two systems could finally result in radiation injury. Therefore, in this prospective cohort study, we explored the association of genetic variants in ROS metabolism and DNA repair pathway-related genes with radiation pneumonitis RP. A total of 265 locally advanced esophageal squamous cell carcinoma ESCC patients receiving RT in Chinese Han population were enrolled. Five functional single nucleotide polymorphisms SNPs rs1695 in GSTP1; rs4880 in SOD2; rs3957356 in GSTA1; and rs1801131, rs1801133 in MTHFR were genotyped using the MassArray system, and rs1801131 was found to be a predictor of ≥ 2 RP. Our results showed that, compared with TT genotype, patients with GG-GT genotypes of rs1801131 had a notably lower risk of developing ≥ 2 RP HR = 0.339, 95% CI = 0.137–0.839, P = 0.019. Further independent studies are required to confirm this findings.



Autor: Yang Zhang , Zongjuan Li , Jian Zhang, Hongsheng Li, Yumei Qiao, Chengsuo Huang, Baosheng Li

Fuente: http://plos.srce.hr/



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