Genome-Wide Association Study for Muscle Fat Content and Abdominal Fat Traits in Common Carp Cyprinus carpioReportar como inadecuado




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Muscle fat content is an important phenotypic trait in fish, as it affects the nutritional, technical and sensory qualities of flesh. To identify loci and candidate genes associated with muscle fat content and abdominal fat traits, we performed a genome-wide association study GWAS using the common carp 250 K SNP assay in a common carp F2 resource population. A total of 18 loci surpassing the genome-wide suggestive significance level were detected for 4 traits: fat content in dorsal muscle MFdo, fat content in abdominal muscle MFab, abdominal fat weight AbFW, and AbFW as a percentage of eviscerated weight AbFP. Among them, one SNP carp089419 affecting both AbFW and AbFP reached the genome-wide significance level. Ten of those loci were harbored in or near known genes. Furthermore, relative expressions of 5 genes related to MFdo were compared using dorsal muscle samples with high and low phenotypic values. The results showed that 4 genes were differentially expressed between the high and low phenotypic groups. These genes are, therefore, prospective candidate genes for muscle fat content: ankyrin repeat domain 10a ankrd10a, tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 tanc2, and four jointed box 1 fjx1 and choline kinase alpha chka. These results offer valuable insights into the complex genetic basis of fat metabolism and deposition.



Autor: Xianhu Zheng, Youyi Kuang, Weihua Lv, Dingchen Cao, Zhipeng Sun, Xiaowen Sun

Fuente: http://plos.srce.hr/



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