Association of ABCB1 and SLC22A16 Gene Polymorphisms with Incidence of Doxorubicin-Induced Febrile Neutropenia: A Survey of Iranian Breast Cancer PatientsReportar como inadecuado




Association of ABCB1 and SLC22A16 Gene Polymorphisms with Incidence of Doxorubicin-Induced Febrile Neutropenia: A Survey of Iranian Breast Cancer Patients - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Breast cancer is the most common cancer in women worldwide. Doxorubicin-based chemotherapy is used to treat breast cancer patients; however, neutropenia is a common hematologic side effect and can be life-threatening. The ABCB1 and SLC22A16 genes encode proteins that are essential for doxorubicin transport. In this study, we explored the effect of 2 common polymorphisms in ABCB1 rs10276036 C-T and SLC22A16 rs12210538 A-G on the development of grade 3-4 febrile neutropenia in Iranian breast cancer patients. Our results showed no significant association between these polymorphisms and grade 3-4 febrile neutropenia; however, allele C of ABCB1 rs10276036 C-T p = 0.315, OR = 1.500, 95% CI = 0.679–3.312 and allele A of SLC22A16 rs12210538 A-G p = 0.110, OR = 2.984, 95% CI = 0.743–11.988 tended to have a greater association with grade 3-4 febrile neutropenia, whereas allele T of ABCB1 rs10276036 p = 0.130, OR = 0.515, 95% CI = 0.217–1.223 and allele G of SLC22A16 rs12210538 p = 0.548, OR = 0.786, 95% CI = 0.358–1.726 tended to protect against this condition. In addition to breast cancer, a statistically significant association was also observed between the development of grade 3-4 febrile neutropenia and other clinical manifestations such as stage IIIC cancer p = 0.037 and other diseases p = 0.026. Our results indicate that evaluation of the risk of grade 3-4 neutropenia development and consideration of molecular and clinical findings may be of value when screening for high-risk breast cancer patients.



Autor: Abolfazl Faraji , Hamid Reza Dehghan Manshadi , Maryam Mobaraki , Mahkameh Zare , Massoud Houshmand

Fuente: http://plos.srce.hr/



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