Antiatherosclerotic and Cardioprotective Potential of Acacia senegal Seeds in Diet-Induced Atherosclerosis in RabbitsReportar como inadecuado

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Biochemistry Research International - Volume 2014 2014, Article ID 436848, 6 pages -

Research Article

Department of Zoology, Jai Narain Vyas University, Jodhpur 342001, India

Molecular Medicine and Toxicology Lab, School of Life Sciences, Devi Ahilya University, Indore, Madhya Pradesh 452001, India

Received 31 July 2014; Accepted 19 November 2014; Published 7 December 2014

Academic Editor: Gary A. Lorigan

Copyright © 2014 Heera Ram et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acacia senegal L. Fabaceae seeds are essential ingredient of “Pachkutta,” a specific Rajasthani traditional food. The present study explored antiatherosclerotic and cardioprotective potential of Acacia senegal seed extract, if any, in hypercholesterolemic diet-induced atherosclerosis in rabbits. Atherosclerosis in rabbits was induced by feeding normal diet supplemented with oral administration of cholesterol 500 mg-kg body weight-day mixed with coconut oil for 15 days. Circulating total cholesterol TC, HDL-cholesterol HDL-C, LDL-cholesterol LDL-C, triglycerides, and VLDL-cholesterol VLDL-C levels; atherogenic index AI; cardiac lipid peroxidation LPO; planimetric studies of aortal wall; and histopathological studies of heart, aorta, kidney, and liver were performed. Apart from reduced atherosclerotic plaques in aorta and increased lumen volume , administration with ethanolic extract of Acacia senegal seeds 500 mg-kg-day, p.o. for 45 days to atherosclerotic rabbits significantly lowered serum TC, LDL-C, triglyceride, and VLDL-C levels and atherogenic index as compared to control. Atherogenic diet-induced cardiac LPO and histopathological abnormalities in aorta wall, heart, kidney, and liver were reverted to normalcy by Acacia senegal seed extract administration. The findings of the present study reveal that Acacia senegal seed extract ameliorated diet-induced atherosclerosis and could be considered as lead in the development of novel therapeutics.

Autor: Heera Ram, Rameshwar Jatwa, and Ashok Purohit



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