Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepiali Water Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley RatsReportar como inadecuado




Studies on the Antidiabetic and Antinephritic Activities of Paecilomyces hepiali Water Extract in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of Diabetes Research - Volume 2016 2016, Article ID 4368380, 10 pages -

Research ArticleSchool of Life Sciences, Jilin University, Changchun 130012, China

Received 3 November 2015; Revised 27 January 2016; Accepted 1 February 2016

Academic Editor: Carlos Martinez Salgado

Copyright © 2016 Juan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Paecilomyces hepiali is a fungus widely used in Asian countries for various potential pharmacological activities. The present study aims to evaluate the antidiabetic and antinephritic effects of the Paecilomyces hepiali mycelium water extract PHC in diabetic rat, which is established by eight-week high-fat diet administration followed by one-week tail intravenous injection of 25 mg-kg streptozotocin STZ. After four-week 0.12 g-kg metformin and PHC at doses of 0.08, 0.4, and 2.0 g-kg treatment, an increment of body weight, a decrement of plasma glucose, low levels of total cholesterol, and low density lipoprotein cholesterol in diabetic rats were observed. PHC promotes glucose metabolism by enhancing insulin, pyruvate kinase activity, and increasing the synthesis of glycogen. PHC normalized the disturbed levels of superoxide dismutase, methane dicarboxylic aldehyde, and glutathione peroxidase in kidney. The inhibitory effects on the levels of interleukin-2, interleukin-6, interleukin-10, and tumor necrosis factor- in serum and kidney revealed the protection of PHC against diabetic nephropathy. Compared with nontreated diabetic rats, four-week PHC treatment resulted in a decrement on nuclear factor kappa B expression in kidney. These results show that Paecilomyces hepiali possesses antidiabetic and antinephritic effects which are related to the modulation of nuclear factor kappa B activity.





Autor: Juan Wang, Lirong Teng, Yange Liu, Wenji Hu, Wenqi Chen, Xi Hu, Yingwu Wang, and Di Wang

Fuente: https://www.hindawi.com/



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