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Parkinson-s DiseaseVolume 2011 2011, Article ID 436813, 9 pages

Review ArticleLaboratorio de Terapias Regenerativas y Protectoras del Sistema Nervioso, Fundación Instituto Leloir, Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina

Received 15 October 2010; Accepted 7 January 2011

Academic Editor: Carlos Barcia

Copyright © 2011 Carina C. Ferrari and Rodolfo Tarelli. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Peripheral inflammation triggers exacerbation in the central brain-s ongoing damage in several neurodegenerative diseases. Systemic inflammatory stimulus induce a general response known as sickness behaviour, indicating that a peripheral stimulus can induce the synthesis of cytokines in the brain. In Parkinson-s disease PD, inflammation was mainly associated with microglia activation that can underlie the neurodegeneration of neurons in the substantia nigra SN. Peripheral inflammation can transform the “primed” microglia into an “active” state, which can trigger stronger responses dealing with neurodegenerative processes. Numerous evidences show that systemic inflammatory processes exacerbate ongoing neurodegeneration in PD patient and animal models. Anti-inflammatory treatment in PD patients exerts a neuroprotective effect. In the present paper, we analyse the effect of peripheral infections in the etiology and progression in PD patients and animal models, suggesting that these peripheral immune challenges can exacerbate the symptoms in the disease.

Autor: Carina C. Ferrari and Rodolfo Tarelli



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