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Case Reports in DentistryVolume 2013 2013, Article ID 404120, 4 pages

Case Report

Department of Periodontology & Implantology, Sharad Pawar Dental College and Hospital, Wardha, Maharashtra 442001, India

Department of Prosthodontics, Sharad Pawar Dental College and Hospital, Wardha, Maharastra 442001, India

Received 10 July 2013; Accepted 25 September 2013

Academic Editors: P. Lopez Jornet and E. F. Wright

Copyright © 2013 Kaustubh Suresh Thakare et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Papillon-Lefevre syndrome PLS is a rare autosomal recessive heterogeneous trait which is characterized by erythematous palmoplantar hyperkeratosis, early-onset periodontitis, and associated calcification of dura mater. The etiology of PLS is multifactorial with genetic, immunological, and microbial factors playing a role in etiopathogenesis. Recently identified genetic defect in PLS has been mapped to chromosome 11q14–q21, which involves mutations of cathepsin C. This paper presents a report of 2 cases of Papillon-lefevre syndrome in which diagnosis is based on clinical presentation and genetic mapping.





Autor: Kaustubh Suresh Thakare, M. L. Bhongade, Pretti Charde, Shweta Kale, Priyanka Jaiswal, B. K. Somnath, and Sunil Pendor

Fuente: https://www.hindawi.com/



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