Preconditioning Serum Levels of Endothelial Cell-Derived Molecules and the Risk of Posttransplant Complications in Patients Treated with Allogeneic Stem Cell TransplantationReportar como inadecuado




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Journal of Transplantation - Volume 2014 2014, Article ID 404096, 9 pages -

Research Article

Section for Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway

Section for Hematology, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway

Received 23 May 2014; Revised 16 August 2014; Accepted 18 August 2014; Published 8 October 2014

Academic Editor: Simon Robson

Copyright © 2014 Roald Lindås et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Endothelial cells are involved in the pathogenesis of acute graft-versus-host disease GVHD after allogeneic stem cell transplantation. These cells express several molecules that can be detected as biologically active soluble forms; serum levels of these molecules may thereby reflect the functional status of endothelial cells. Furthermore, acute GVHD is an inflammatory reaction and endothelial cells function as local regulators of inflammation. We therefore investigated whether differences in preconditioning-pretransplant serum levels of endothelium-expressed molecules i.e., endocan, vascular cell adhesion molecule 1 VCAM-1, and E-selectin were associated with a risk of posttransplant GVHD. Our study should be regarded as a population-based study of consecutive and thereby unselected patients . Analysis of this pretreatment endothelium biomarker profile by unsupervised hierarchical clustering identified a subset of patients with increased early nonrelapse mortality. Furthermore, low endocan levels were significantly associated with acute GVHD in the liver and gastrointestinal tract, whereas high VCAM-1 levels were associated with acute GVHD in the skin only. Our study suggests that the preconditioning-pretransplant status of endothelial cells possibly through altered trafficking of immunocompetent cells is important for the risk and the organ involvement of later acute GVHD.





Autor: Roald Lindås, Tor Henrik Andersson Tvedt, Kimberley Joanne Hatfield, Håkon Reikvam, and Øystein Bruserud

Fuente: https://www.hindawi.com/



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