Perfluorinated Acids in Human Serum as Determinants of Maternal HypothyroxinemiaReportar como inadecuado




Perfluorinated Acids in Human Serum as Determinants of Maternal Hypothyroxinemia - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Perfluorinated acids, thyroid hormone

Chan, Emily

Supervisor and department: Martin, Jonathan W Public Health Sciences-Laboratory Medicine and Pathology

Examining committee member and department: Bamforth, Fiona Laboratory Medicine and Pathology Burstyn, Igor Medicine Senthiselvan, A School of Public Health Cherry, Nicola Medicine

Department: School of Public Health

Specialization:

Date accepted: 2010-04-14T15:57:48Z

Graduation date: 2010-06

Degree: Master of Science

Degree level: Master's

Abstract: Perfluorinated acids PFAs are widespread global and human blood organohalogen contaminants. These monomer decomposition products used in surface treatment products and in fluoropolymer manufacturing and fire fighting may disrupt maternal thyroid hormone homeostasis given that animal studies demonstrate an apparent hypothyroxinemic condition upon PFA exposure. Firstly, we developed a method for properly quantifying perfluorohexane sulfonate PFHxS, a PFA suspected of overreporting in past literature. We then investigated whether perfluorooctanoate PFOA, PFHxS and perfluorooctane sulfonate PFOS were determinants of maternal hypothyroxinemia in a pregnant women population from Edmonton using a case-control design. Free thyroxine fT4 and thyroid stimulating hormone TSH were screened in 974 women collected during 15-20 weeks of pregnancy. Cases n=96, hypothyroxinemic: normal TSH and fT4: lowest 10th percentile and controls n=175, fT4: 50th and 90th percentile were matched based on age and physician. Conditional logistic regression indicated that these PFAs are not associated with maternal hypothyroxinemia.

Language: English

DOI: doi:10.7939-R3XD71

Rights: License granted by Emily Chan ec9@ualberta.ca on 2010-04-13T23:30:54Z GMT: Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.





Autor: Chan, Emily

Fuente: https://era.library.ualberta.ca/


Introducción



University of Alberta Perfluorinated Acids in Human Serum as Determinants of Maternal Hypothyroxinemia by Emily Chan A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science in Environmental Health Sciences School of Public Health © Emily Chan Spring 2010 Edmonton, Alberta Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only.
Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the authors prior written permission. Examining Committee Dr.
Fiona Bamforth, Department of Laboratory Medicine and Pathology, University of Alberta Dr.
Igor Burstyn, Department of Medicine, University of Alberta Dr.
Nicola Cherry, Department of Medicine, University of Alberta Dr.
Jonathan Martin, Department of Public Health Sciences- Department of Laboratory Medicine and Pathology, University of Alberta Dr.
A Senthiselvan, School of Public Health, University of Alberta Dedications This work is foremost dedicated to my family for their support throughout the years. Abstract Perfluorinated acids (PFAs) are widespread global and human blood organohalogen contaminants.
These monomer decomposition products used in surface treatment products and in fluoropolymer manufacturing and fire fighting may disrupt maternal thyroid hormone homeostasis given that animal studies demonstrate an apparent hypothyroxinemic condition upon PFA exposure.
Firstly, we developed a me...





Documentos relacionados