Is Time to Reach EDSS 6.0 Faster in Patients with Late-Onset versus Young-Onset Multiple SclerosisReportar como inadecuado

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Background and Objectives

Published natural history data on late-onset of multiple sclerosis are limited. We aimed to assess the risk of attaining EDSS 6.0 among patients with late-onset > 40 years MS LOMS and young-onset 18–40 years MS YOMS.


This cross-sectional cohort study was conducted to identify LOMS and YOMS patients’ with relapsing remitting course at MS diagnosis. Time years to reach sustained EDSS 6.0 was compared between LOMS and AOMS patients. Cox proportional hazards model was used to evaluate the demographic and clinical predictors of time to EDSS 6.0 in these cohorts.


LOMS and YOMS cohorts comprised 99 10.7% and 804 89.3% patients respectively. Spinal cord presentation at MS onset was more common among LOMS patients 46.5% vs. 32.3%. The proportions of LOMS and YOMS patients reaching EDSS 6.0 during the follow-up period were 19.2% and 15.7% respectively. In multivariable Cox proportional hazards model, older age at MS onset adjusted hazard ratio aHR = 3.96; 95% CI: 2.14–7.32; p < 0.001, male gender aHR = 1.85; 95% CI: 1.22–2.81; p = 0.004 and spinal cord presentation at onset aHR = 1.47; 95% CI: 0.98–2.21; p = 0.062 were significantly associated with shorter time to EDSS 6.0.


LOMS patients attained EDSS 6.0 in a significantly shorter period that was influenced by male gender and spinal cord presentation at MS onset.

Autor: Raed Alroughani , Saeed Akhtar, Samar Ahmed, Raed Behbehani, Jasem Al-Hashel



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