Circulating Omega-6, But Not Omega-3 Polyunsaturated Fatty Acids, Are Associated with Clinical Outcomes in Patients with Acute Decompensated Heart FailureReportar como inadecuado




Circulating Omega-6, But Not Omega-3 Polyunsaturated Fatty Acids, Are Associated with Clinical Outcomes in Patients with Acute Decompensated Heart Failure - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

Circulating polyunsaturated fatty acid PUFA levels are associated with clinical outcomes in cardiovascular diseases including coronary artery disease and chronic heart failure HF. However, their clinical implications in acute decompensated HF ADHF remain unclear. The aim of this study was to investigate the clinical roles of circulating PUFAs in patients with ADHF.

Methods

Circulating levels of PUFAs, eicosapentaenoic acid EPA, docosahexaenoic acid DHA, arachidonic acid AA and dihomo-gamma linoleic acid DGLA, were measured on admission in 685 consecutive ADHF patients. Adverse events were defined as all-cause death and worsening HF.

Results

During a median follow-up period of 560 days, 262 38.2% patients had adverse events. Although patients with adverse events had lower n-6 PUFA AA + DGLA level than those without, n-3 PUFA EPA + DHA level was comparable between the groups. Kaplan-Meier analyses showed that lower n-6 PUFA level on admission was significantly associated with the composite of all-cause death and worsening HF, all-cause death, cardiovascular death and worsening HF p < 0.001, p = 0.005, p = 0.021, p = 0.019, respectively. In a multivariate Cox model, lower n-6 PUFA level was independently associated with increased risk of adverse events HR 0.996, 95% CI: 0.993–0.999, p = 0.027.

Conclusions

Lower n-6 but not n-3 PUFA level on admission was significantly related to worse clinical outcomes in ADHF patients. Measurement of circulating n-6 PUFA levels on admission might provide information for identifying high risk ADHF patients.



Autor: Toshiyuki Nagai , Yasuyuki Honda, Yasuo Sugano, Kunihiro Nishimura, Michikazu Nakai, Satoshi Honda, Naotsugu Iwakami, Atsushi Oka

Fuente: http://plos.srce.hr/



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