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Journal of Biomedicine and BiotechnologyVolume 2010 2010, Article ID 150960, 13 pages

Review Article

Laboratory of Experimental Medicine, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 775 20 Olomouc, Czech Republic

Department of Experimental Medicine and Department of Human Genetics, McGill University, Montreal, Canada H3G 1A4

Received 14 August 2009; Revised 22 February 2010; Accepted 9 March 2010

Academic Editor: Dominic Fan

Copyright © 2010 Sylwia Jančík et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The KRAS gene Ki-ras2 Kirsten rat sarcoma viral oncogene homolog is an oncogene that encodes a small GTPase transductor protein called KRAS. KRAS is involved in the regulation of cell division as a result of its ability to relay external signals to the cell nucleus. Activating mutations in the KRAS gene impair the ability of the KRAS protein to switch between active and inactive states, leading to cell transformation and increased resistance to chemotherapy and biological therapies targeting epidermal growth factor receptors. This review highlights some of the features of the KRAS gene and the KRAS protein and summarizes current knowledge of the mechanism of KRAS gene regulation. It also underlines the importance of activating mutations in the KRAS gene in relation to carcinogenesis and their importance as diagnostic biomarkers, providing clues regarding human cancer patients- prognosis and indicating potential therapeutic approaches.





Autor: Sylwia Jančík, Jiří Drábek, Danuta Radzioch, and Marián Hajdúch

Fuente: https://www.hindawi.com/



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