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International Journal of Cell BiologyVolume 2013 2013, Article ID 150952, 19 pages

Review Article

Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati SISSA, Via Bonomea 265, 34136 Trieste, Italy

Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy

Received 17 May 2013; Accepted 3 September 2013

Academic Editor: Roberto Chiesa

Copyright © 2013 Suzana Aulić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Prion diseases are fatal neurodegenerative illnesses, which include Creutzfeldt-Jakob disease in humans and scrapie, chronic wasting disease, and bovine spongiform encephalopathy in animals. They are caused by unconventional infectious agents consisting primarily of misfolded, aggregated, β-sheet-rich isoforms, denoted prions, of the physiological cellular prion protein . Many lines of evidence suggest that prions act both as a template for this conversion and as a neurotoxic agent causing neuronal dysfunction and cell death. As such, may be considered as both a neuropathological hallmark of the disease and a therapeutic target. Several diagnostic imaging probes have been developed to monitor cerebral amyloid lesions in patients with neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and prion disease. Examples of these probes are Congo red, thioflavin T, and their derivatives. We synthesized a series of styryl derivatives, denoted theranostics, and studied their therapeutic and-or diagnostic potentials. Here we review the salient traits of these small molecules that are able to detect and modulate aggregated forms of several proteins involved in protein misfolding diseases. We then highlight the importance of further studies for their practical implications in therapy and diagnostics.





Autor: Suzana Aulić, Maria Laura Bolognesi, and Giuseppe Legname

Fuente: https://www.hindawi.com/



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