Performance Evaluation of the MyT4 Technology for Determining ART EligibilityReportar como inadecuado




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Background

In resource-limited countries, CD4 T-cell CD4 testing continues to be used for determining antiretroviral therapy ART initiation eligibility and opportunistic infection monitoring. To support expanded access to CD4 testing, simple and robust technologies are necessary. We conducted this study to evaluate the performance of a new Point-of-Care POC CD4 technology, the MyT4, compared to conventional laboratory CD4 testing.

Methods

EDTA venous blood from 200 HIV-positive patients was tested in the laboratory using the MyT4 and BD FACSCalibur™.

Results

The MyT4 had an r2 of 0.82 and a mean bias of 12.3 cells-μl. The MyT4 had total misclassifications of 14.7% and 8.8% when analyzed using ART eligibility thresholds of 350 and 500 cells-μl, respectively.

Conclusions

We conclude that the MyT4 performed well in classifying patients using the current ART initiation eligibility thresholds in Mozambique when compared to the conventional CD4 technology.



Autor: Nádia Sitoe , Rosa Macamo, Bindiya Meggi, Ocean Tobaiwa, Osvaldo Loquiha, Timothy Bollinger, Lara Vojnov, Ilesh Jani

Fuente: http://plos.srce.hr/



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