Quantitative T1, T2, and T2* Mapping and Semi-Quantitative Neuromelanin-Sensitive Magnetic Resonance Imaging of the Human MidbrainReportar como inadecuado




Quantitative T1, T2, and T2* Mapping and Semi-Quantitative Neuromelanin-Sensitive Magnetic Resonance Imaging of the Human Midbrain - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Purpose

Neuromelanin is a dark pigment granule present within certain catecholamine neurons of the human brain. Here, we aimed to clarify the relationship between contrast of neuromelanin-sensitive magnetic resonance imaging MRI and MR relaxation times using T1, T2, and T2* mapping of the lower midbrain.

Methods

The subjects were 14 healthy volunteers 11 men and 3 women, mean age 29.9 ± 6.9 years. Neuromelanin-sensitive MRI was acquired using an optimized T1-weighted two-dimensional 2D-turbo spin-echo sequence. To quantitatively evaluate the relaxation time, 2D-image data for the T1, T2, and T2* maps were also acquired. The regions of interest substantia nigra pars compacta SNc, superior cerebellar peduncles SCP, cerebral peduncles CP, and midbrain tegmentum MT were manually drawn on neuromelanin-sensitive MRI to measure the contrast ratio CR and on relaxation maps to measure the relaxation times.

Results

The CR in the SNc was significantly higher than the CRs in the SCP and CP. Compared to the SCP and CP, the SNc had significantly higher T1 relaxation times. Moreover, the SNc had significantly lower T2 and T2* relaxation times than the other three regions SCP, CP, and MT. Correlation analyses showed no significant correlations between the CRs in the SNc, SCP, and CP and each relaxation time.

Conclusions

We demonstrated the relationship between the CR of neuromelanin-sensitive MRI and the relaxation times of quantitative maps of the human midbrain.



Autor: Takashi Hashido , Shigeyoshi Saito

Fuente: http://plos.srce.hr/



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