The Associations of Serum Lipids with Vitamin D StatusReportar como inadecuado

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Vitamin D deficiency has been associated with some disorders including cardiovascular diseases. Dyslipidemia is a major risk factor for cardiovascular diseases. However, data about the relationships between vitamin D and lipids are inconsistent. The relationship of vitamin D and Atherogenic Index of Plasma AIP, as an excellent predictor of level of small and dense LDL, has not been reported. The objective of this study was to investigate the effects of vitamin D status on serum lipids in Chinese adults.


The study was carried out using 1475 participants from the Center for Physical Examination, 306 Hospital of PLA in Beijing, China. Fasting blood samples were collected and serum concentrations of 25OHD, total cholesterol TC, triglyceride TG, high density lipoprotein cholesterol HDL-C and low density lipoprotein cholesterol LDL-C were measured. AIP was calculated based on the formula: log TG-HDL-C. Multiple linear regression analysis was used to estimate the associations between serum 25OHD and lipids. The association between the occurrences of dyslipidemias and vitamin D levels was assessed by multiple logistic regression analysis. Confounding factors, age and BMI, were used for the adjustment.


The median of serum 25OHD concentration was 47 27–92.25 nmol-L in all subjects. The overall percentage of 25OHD ≦ 50 nmol-L was 58.5% males 54.4%, females 63.7%. The serum 25OHD levels were inversely associated with TG β coefficient = -0.24, p < 0.001 and LDL-C β coefficient = -0.34, p < 0.001 and positively associated with TC β coefficient = 0.35, p < 0.002 in men. The associations between serum 25OHD and LDL-C β coefficient = -0.25, p = 0.01 and TC β coefficient = 0.39, p = 0.001 also existed in women. The serum 25OHD concentrations were negatively associated with AIP in men r = -0.111, p < 0.01 but not in women. In addition, vitamin D deficient men had higher AIP values than vitamin D sufficient men. Furthermore, the occurrences of dyslipidemias reduced HDL-C, elevated TG and elevated AIP correlated with lower 25OHD levels in men, whereas the higher TC and LDL-C associated with higher 25OHD levels in women.


It seems that the serum 25OHD levels are closely associated with the serum lipids and AIP. Vitamin D deficiency may be associated with the increased risk of dyslipidemias, especially in men. The association between vitamin D status and serum lipids may differ by genders.

Autor: Ying Wang , Shaoyan Si , Junli Liu, Zongye Wang, Haiying Jia, Kai Feng, Lili Sun, Shu Jun Song



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