Morin Flavonoid Adsorbed on Mesoporous Silica, a Novel Antioxidant NanomaterialReportar como inadecuado

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Morin 2,3, 4,5,7-pentahydroxyflavone is a flavonoid with several beneficial health effects. However, its poor water solubility and it sensitivity to several environmental factors avoid its use in applications like pharmaceutical and cosmetic. In this work, we synthetized morin-modified mesoporous silica nanoparticles AMSNPs-MOR as useful material to be used as potential nanoantioxidant. To achieve this, we characterized its adsorption kinetics, isotherm and the antioxidant capacity as hydroxyl radical HO• scavenger and singlet oxygen 1O2 quencher. The experimental data could be well fitted with Langmuir, Freundlich and Temkin isotherm models, besides the pseudo-second order kinetics model. The total quenching rate constant obtained for singlet oxygen deactivation by AMSNPs-MOR was one order of magnitude lower than the morin rate constant reported previously in neat solvents and lipid membranes. The AMSNPs-MOR have good antioxidant properties by itself and exhibit a synergic effect with morin on the antioxidant property against hydroxyl radical. This effect, in the range of concentrations studied, was increased when the amount of morin adsorbed increased.

Autor: Francisco Arriagada, Olosmira Correa, Germán Günther, Santi Nonell, Francisco Mura, Claudio Olea-Azar, Javier Morales



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