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ScientificaVolume 2014 2014, Article ID 901586, 11 pages

Review ArticleCardiology Division, Duke University Hospital, 2301 Erwin Road, DUMC 3845, Durham, NC 27710, USA

Received 24 February 2014; Accepted 24 June 2014; Published 19 August 2014

Academic Editor: Lei Xi

Copyright © 2014 Meena P. Rao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Atrial fibrillation is the most common arrhythmia and accounts for one-third of hospitalizations for rhythm disorders in the United States. The prevalence of atrial fibrillation averages 1% and increases with age. With the aging of the population, the number of patients with atrial fibrillation is expected to increase 150% by 2050, with more than 50% of atrial fibrillation patients being over the age of 80. This increasing burden of atrial fibrillation will lead to a higher incidence of stroke, as patients with atrial fibrillation have a five- to sevenfold greater risk of stroke than the general population. Strokes secondary to atrial fibrillation have a worse prognosis than in patients without atrial fibrillation. Vitamin K antagonists e.g., warfarin, direct thrombin inhibitors dabigatran, and factor Xa inhibitors rivaroxaban and apixaban are all oral anticoagulants that have been FDA approved for the prevention of stroke in atrial fibrillation. This review will summarize the experience of anticoagulants in patients with atrial fibrillation with a focus on the experience at the Duke Clinic Research Institute.





Autor: Meena P. Rao, Sean D. Pokorney, and Christopher B. Granger

Fuente: https://www.hindawi.com/



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