Short-Term Bisphosphonate Therapy Could Ameliorate Osteonecrosis: A Complication in Childhood Hematologic MalignanciesReportar como inadecuado




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Case Reports in MedicineVolume 2010 2010, Article ID 206132, 5 pages

Case Report

Pediatric Endocrinology and Adolescence, Department of Pediatrics, Hospital-University of Padova, 35128 Padova, Italy

Hemo-Oncology, Department of Pediatrics, Hospital-University of Padova, 35128 Padova, Italy

Pediatric Radiology, Department of Pediatrics, Hospital-University of Padova, 35128 Padova, Italy

Pharmacy, Veneto Oncology Institute - IRCCS, 35128 Padova, Italy

Received 6 March 2010; Accepted 25 April 2010

Academic Editor: Werner Rabitsch

Copyright © 2010 N. A. Greggio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Osteonecrosis ON is a critical complication in the treatment of childhood leukemia and lymphoma. Itparticularly affects survivors of acute lymphoblastic leukemia and non-Hodgkin lymphoma reflecting thecumulative exposure to glucocorticosteroid therapy. ON is often multiarticular and bilateral, speciallyaffecting weight-bearing joints. A conventional approach suggests a surgical intervention even ifpharmacological options have also recently been investigated. We reported two cases of long time steroid-treated patients who underwent Bone Marrow Transplantation BMT for hematological disease. Bothpatients developed femoral head osteonecrosis ON that was diagnosed by magnetic resonance imagingMRI and the ON was also accompanied with pain and a limp. Despite of the conventional strategies oftherapy, we successfully started a short-term treatment with bisphosphonates in order to decrease the painand the risk of fracture.





Autor: N. A. Greggio, M. Pillon, E. Varotto, A. Zanin, E. Talenti, A. C. Palozzo, E. Calore, and C. Messina

Fuente: https://www.hindawi.com/



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