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Evidence-Based Complementary and Alternative Medicine - Volume 2017 2017, Article ID 8985623, 11 pages - https:-doi.org-10.1155-2017-8985623

Research Article

Department of Combination of Chinese and Western Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Department of Traditional Chinese Medicine for Tumor, Chongqing Cancer Institute, Chongqing 400030, China

Department of Rehabilitation Medicine, The Affiliated Rehabilitation Hospital of Chongqing Medical University, Chongqing 400016, China

Correspondence should be addressed to Rong Heng Li

Received 12 October 2016; Revised 23 November 2016; Accepted 24 November 2016; Published 11 January 2017

Academic Editor: Antonella Fioravanti

Copyright © 2017 Li Zeng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Fu Yuan Capsule FYC has been clinically used for osteoarthritis OA and its related diseases for many years in China. However, its pharmacological mechanism remains unclear. This study aimed to investigate the potential chondroprotective effects of FYC on articular cartilage. Rat OA model was induced by anterior cruciate ligament transection. A group of rats was treated with FYC for 12 weeks. Joint structure, types I and II collagen, and proteoglycan were evaluated by histological examination. The expression of C-terminal crosslinking telopeptide of type II collagen, hydroxyproline, a disintegrin and metalloproteinase with thrombospondin motifs, matrix metalloproteinase, interleukin-1 beta, nitric oxide, prostaglandin E2, heat-shock protein 70, transforming growth factor-beta, osteoprotegerin, and receptor activator of nuclear factor κB ligand were detected. Treatment with FYC could protect against articular cartilage injury. FYC treatment significantly decreased the extracellular matrix degradation factors and inflammatory mediators. Moreover, articular cartilage protective factors were increased in the FYC group. The current finding suggests that FYC protects articular cartilage in a rat OA model through various ways. Thus, it may be an effective agent for OA treatment.





Autor: Li Zeng, Cai Zhi Xiao, Zi Ting Deng, and Rong Heng Li

Fuente: https://www.hindawi.com/



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