A Novel Dietary Supplement Containing Multiple Phytochemicals and Vitamins Elevates Hepatorenal and Cardiac Antioxidant Enzymes in the Absence of Significant Serum Chemistry and Genomic ChangesReportar como inadecuado




A Novel Dietary Supplement Containing Multiple Phytochemicals and Vitamins Elevates Hepatorenal and Cardiac Antioxidant Enzymes in the Absence of Significant Serum Chemistry and Genomic Changes - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Oxidative Medicine and Cellular Longevity - Volume 3 2010, Issue 2, Pages 129-144



Molecular Toxicology Laboratories, Division of Pharmaceutical Sciences, A Ȇ M Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, USA

Creighton University School of Pharmacy and Allied Health Professions, Omaha, NE, USA

Received 21 January 2010; Revised 29 January 2010; Accepted 1 February 2010

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A novel dietary supplement composed of three well-known phytochemicals, namely, Salvia officinalis sage extract, Camellia sinensis oolong tea extract, and Paullinia cupana guarana extract, and two prominent vitamins thiamine and niacin was designed to provide nutritional support by enhancing metabolism and maintaining healthy weight and energy. The present study evaluated the safety of this dietary supplement STG; S, sage; T, tea; G, guarana and assessed changes in target organ antioxidant enzymes liver, kidneys and heart, serum chemistry profiles and organ histopathology in Fisher 344 rats. Adult male and female Fisher 344 rats were fed control no STG or STG containing 1X and 7X, 1X = daily human dose diets and sacrificed after 2 and 4 months. Serum chemistry analysis and histopathological examination of three vital target organs disclosed no adverse influence on protein, lipid and carbohydrate profiles, genomic integrity of the liver and-or the tissue architecture. However, analysis of the most important antioxidant components in the liver, kidney and heart homogenates revealed a dramatic increase in total glutathione concentrations, glutathione peroxidase and superoxide dismutase enzyme activities. Concomitantly, oxidative stress levels malondialdehyde accumulation in these three organs were less than control. Organ specific serum markers ALT-AST for the liver; CPK-AST-LDH for the heart; BUN-creatinine for kidneys and the genomic integrity disclosed no STG-induced alteration. Some of the serum components lipid and protein showed insignificant changes. Overall, STG-exposed rats were more active, and the results suggest that STG exposure produces normal serum chemistry coupled with elevated antioxidant capacity in rats fed up to seven times the normal human dose and does not adversely influence any of the vital target organs. Additionally, this study reiterates the potential benefits of exposure to a pharmacologically relevant combination of phytochemicals compared to a single phytochemical entity.





Autor: Elida Bulku, Daniel Zinkovsky, Payal Patel, Vishal Javia, Tejas Lahoti, Inna Khodos, Sidney J. Stohs, and Sidhartha D. Ray

Fuente: https://www.hindawi.com/



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