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Journal of Tropical MedicineVolume 2012 2012, Article ID 950303, 7 pages

Research ArticleInstituto de Virología, Universidad El Bosque, Carrera 7B Bis No. 132-11, Bogotá, Colombia

Received 19 October 2011; Accepted 19 December 2011

Academic Editor: Carlos E. P. Corbett

Copyright © 2012 Jeanette Prada-Arismendy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Infection with dengue virus presents a broad clinical spectrum, which can range from asymptomatic cases to severe cases that are characterised by haemorrhagic syndrome and-or shock. The reason for such variability remains unknown. This work evaluated the in vitro permissiveness of mouse, rat, hamster and guinea pig macrophages to infection by dengue virus 2 DENV2. The results established that macrophages derived from the BALB-c mouse strain showed higher permissiveness to DENV2 infection than macrophages from other rodent species, although all rodent species studied had the C820T mutation in the oligoadenylate synthetase 1b gene, indicating no relationship to the different in vitro susceptibilities of mouse cells at this locus. Other molecular mechanisms related to flavivirus susceptibility remain to be explored.





Autor: Jeanette Prada-Arismendy, Verónica Rincón, and Jaime E. Castellanos

Fuente: https://www.hindawi.com/



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