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Canadian Journal of Gastroenterology and Hepatology - Volume 29 2015, Issue 3, Pages 157-163

Review

Division of Internal Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Department of Medicine, King Faisal Special Hospital and Research Centre, Saudi Arabia

Department of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia

Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Received 15 November 2014; Accepted 5 December 2014

Copyright © 2015 Hindawi Publishing Corporation. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License CC BY-NC http:-creativecommons.org-licenses-by-nc-4.0-, which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes.

Abstract

Given the number of inflammatory disorders affecting the gastrointestinal tract directly and indirectly, coupled with the considerable overlap with functional disorders, it is evident that more useful noninvasive diagnostic tests are required to aid with diagnosis. If these tests can also have some utility for individual patient follow-up in terms of disease activity and response to treatment, as well as providing forewarning of disease relapse, it would be extremely useful information for the clinician. One recently described test that may fulfill several of these attributes is based on leakage of a mononuclear cell cytoplasmic protein, calprotectin, along the intestinal tract, which can then be quantified in feces. This has been used to distinguish patients exhibiting symptoms of irritable bowel syndrome from patients with inflammatory bowel disease, with a measure of success greater than with currently used techniques. The present article summarizes the experience with this test used in inflammatory bowel disease, as well as a variety of gastrointestinal disorders.





Autor: Bashaar Alibrahim, Mohammed I Aljasser, and Baljinder Salh

Fuente: https://www.hindawi.com/



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