Differences in the Epidemiology of Childhood Infections with Avian Influenza A H7N9 and H5N1 VirusesReportar como inadecuado




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The difference between childhood infections with avian influenza viruses AH5N1 and AH7N9 remains an unresolved but critically important question. We compared the epidemiological characteristics of 244 H5N1 and 41 H7N9 childhood cases <15 years old, as well as the childhood cluster cases of the two viruses. Our findings revealed a higher proportion of H5N1 than H7N9 childhood infections 31.1% vs. 6.4%, p = 0.000. However, the two groups did not differ significantly in age median age: 5.0 vs. 5.5 y, p = 0.0651. The proportion of clustered cases was significantly greater among children infected with H5N1 than among children infected with H7N9 46.7% 71-152 vs. 23.6% 13-55, p = 0.005, and most of the childhood cases were identified as secondary cases 46.4% 45-97 vs. 33.3% 10-30, p = 0.000. Mild status accounted for 79.49% and 22.66%, severe status for 17.95% and 2.34%, and fatal cases for 2.56% and 75.00% of the H7N9 and H5N1 childhood infection cases all p<0.05, respectively. The fatality rates for the total, index and secondary childhood cluster cases were 52.86% 37-70, 88.5% 23-26 and 33.33% 15-45, respectively, in the H5N1 group, whereas no fatal H7N9 childhood cluster cases were identified. In conclusion, lower severity and greater transmission were found in the H7N9 childhood cases than in the H5N1 childhood cases.



Autor: Jianping Sha , Wei Dong , Shelan Liu , Xiaowen Chen, Na Zhao, Mengyun Luo, Yuanyuan Dong, Zhiruo Zhang

Fuente: http://plos.srce.hr/



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