Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC PatientsReportar como inadecuado




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Previous studies have indicated that carcinoembryonic antigen CEA and cancer antigen 15–3 CA15-3 levels are both independent prognostic factors in breast cancer. However, the utility of CEA and CA15-3 levels as conventional cancer biomarkers in patients with triple-negative breast cancer TNBC remains controversial. The current study was performed to explore the predictive value of pre-therapeutic serum CEA and CA15-3 levels, and nomograms were developed including these serum cancer biomarkers to improve the prognostic evaluation of TNBC patients. Pre-therapeutic CA15-3 and CEA concentrations were measured in 247 patients with stage I–IV TNBC. Kaplan-Meier analysis showed that TNBC patients with high levels of both CEA and CA15-3 had shorter overall survival OS and disease-free survival DFS rates than those in the low-level groups p<0.05. Multivariate analysis suggested that pre-therapeutic CA15-3 and CEA levels are independent predictive elements for OS p = 0.022 and p = 0.040, respectively and DFS p = 0.023 and p = 0.028, respectively. In addition, novel nomograms were established and validated to provide personal forecasts of OS and DFS for patients with TNBC. These novel nomograms may help physicians to select the optimal treatment plans to ensure the best outcomes for TNBC patients.



Autor: Danian Dai , Bo Chen , Hailin Tang , Bin Wang , Zhiping Zhao , Xiaoming Xie , Weidong Wei

Fuente: http://plos.srce.hr/



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