Long-Term Effects of a Randomised Controlled Trial Comparing High Protein or High Carbohydrate Weight Loss Diets on Testosterone, SHBG, Erectile and Urinary Function in Overweight and Obese MenReportar como inadecuado




Long-Term Effects of a Randomised Controlled Trial Comparing High Protein or High Carbohydrate Weight Loss Diets on Testosterone, SHBG, Erectile and Urinary Function in Overweight and Obese Men - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Introduction

Obesity is associated with reduced testosterone and worsened erectile and sexual function in men. Weight loss improves these outcomes. High protein diets potentially offer anthropometric and metabolic benefits, but their effects on reproductive and sexual outcomes is not known.

Aim

To examine the long-term effects of weight loss with a higher protein or carbohydrate diet on testosterone, sex hormone binding globulin, erectile dysfunction, lower urinary tract symptoms and sexual desire in overweight and obese men.

Methods

One-hundred and eighteen overweight or obese men body mass index 27–40 kg-m2, age 20–65 years were randomly assigned to an energy restricted higher protein low fat 35% protein, 40% carbohydrate, 25% fat; n = 57 or higher carbohydrate low fat diet 17% protein, 58% carbohydrate, 25% fat, n = 61 diet for 52 weeks 12 weeks weight loss, 40 weeks weight maintenance. Primary outcomes were serum total testosterone, sex hormone binding globulin and calculated free testosterone. Secondary outcomes were erectile function as assessed by the International Index of Erectile Function IIEF total score and erectile function domain, lower urinary tract symptoms and sexual desire.

Results

Total testosterone, sex hormone binding globulin and free testosterone increased P<0.001 and the total IIEF increased P = 0.017 with no differences between diets P≥0.244. Increases in testosterone P = 0.037 and sex hormone binding globulin P<0.001 and improvements in the total IIEF P = 0.041 occurred from weeks 0–12 with a further increase in testosterone from week 12–52 P = 0.002. Increases in free testosterone occurred from week 12–52 p = 0.002. The IIEF erectile functon domain, lower urinary tract symptoms and sexual desire did not change in either group P≥0.126.

Conclusions

In overweight and obese men, weight loss with both high protein and carbohydrate diets improve testosterone, sex hormone binding globulin and overall sexual function.

Trial Registration

Anzctr.org.au ACTRN12606000002583



Autor: Lisa J. Moran , Grant D. Brinkworth, Sean Martin, Thomas P. Wycherley, Bronwyn Stuckey, Janna Lutze, Peter M. Clifton, Gary A. Wi

Fuente: http://plos.srce.hr/



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