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Background

Limited data is available on the role of prenatal nutritional status on the health of school-age children. We aimed to determine the impact of maternal micronutrient supplementation on the health status of Bangladeshi children.

Methods

Children 8.6–9.6 years; n = 540 were enrolled from a longitudinal mother-child cohort, where mothers were supplemented daily with either 30mg iron and 400μg folic acid Fe30F, or 60mg iron and 400μg folic acid Fe60F, or Fe30F including 15 micronutrients MM, in rural Matlab. Blood was collected from children to determine the concentration of hemoglobin Hb and several micronutrients. Anthropometric and Hb data from these children were also available at 4.5 years of age and mothers at gestational week GW 14 and 30.

Results

MM supplementation significantly improved p≤0.05 body mass index-for-age z-score BAZ, but not Hb levels, in 9 years old children compared to the Fe30F group. MM supplementation also reduced markers of inflammation p≤0.05. About 28%, 35% and 23% of the women were found to be anemic at GW14, GW30 and both time points, respectively. The prevalence of anemia was 5% and 15% in 4.5 and 9 years old children, respectively. The adjusted odds of having anemia in 9 year old children was 3-fold higher if their mothers were anemic at both GW14 and GW30 Odds Ratio OR = 3.05; 95% Confidence Interval CI 1.42, 6.14, P = 0.002 or even higher if they were also anemic at 4.5 years of age OR = 5.92; 95% CI 2.64, 13.25; P<0.001.

Conclusion

Maternal micronutrient supplementation imparted beneficial effects on child health. Anemia during pregnancy and early childhood are important risk factors for the occurrence of anemia in school-age children.



Autor: Tania Mannan, Sultan Ahmed, Evana Akhtar, Anjan Kumar Roy, Md Ahsanul Haq, Adity Roy, Maria Kippler, Eva-Charlotte Ekström, Yuki

Fuente: http://plos.srce.hr/



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