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Purpose

To evaluate the utility of urine protein-creatinine ratio uPCR measurements among healthy parturients at term we performed a prospective cohort study at a community teaching hospital.

Methods

Serial urine samples were collected. Ninety-three women contributed 284 urine samples. uPCRs were determined. Multiple imputation and paired sampled analysis was performed when appropriate.

Results

Two-thirds 63-93 of women had at least one measured uPCR ≥ 0.3. One-third 31-93 had a uPCR ≥ 0.3 at admission, including 39.1% 9-23 of women not in labor. Median IQR uPCRs increased during labor and after delivery: latent phase-no labor, 0.15 0.06–0.32; active phase, 0.29 0.10–0.58; early postpartum, 0.45 0.18–1.36 all p < 0.04. Median uPCRs were significantly < 0.3 in the latent phase and significantly > 0.3 in the immediate postpartum period p < 0.01. Women who labored before cesarean delivery had the highest early postpartum uPCRs: median IQR 1.16 0.39–1.80. A negative urine dipstick protein result did not exclude uPCR ≥ 0.3. uPCRs were similar when compared by method of urine collection.

Conclusion

uPCR ≥ 0.3 is common among healthy women with uncomplicated pregnancies at term. uPCR increases during labor and is not a reliable measure of pathologic proteinuria at term or during the peripartum period.



Autor: Vaya W. Tanamai, Brandon-Luke L. Seagle, Judy Y. Yeh, Bethany Brady, Corrie B. Miller, Salvador Sena, Jessica Dodge, Shohreh Shah

Fuente: http://plos.srce.hr/



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