Post-Inhaled Corticosteroid Pulmonary Tuberculosis Increases Lung Cancer in Patients with AsthmaReport as inadecuate




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Purpose

To evaluate the association between post-inhaled corticosteroid ICS pulmonary tuberculosis TB, pneumonia and lung cancer in patients with asthma.

Methods

The study samples were collected from the National Health Insurance Database. Asthmatic patients who were first-time users of ICS between 2003 and 2005 were identified as cases. For each case, 4 control individuals were randomly matched for sex, age and date of ICS use. Cases and matched controls were followed up until the end of 2010. Cox proportional hazard regression was used to determine the hazard ratio for pulmonary infections and lung cancer risk in the ICS users and non-users.

Results

A total of 10,904 first-time users of ICS were matched with 43,616 controls. The hazard ratios for lung cancer were: 2.52 95% confidence interval CI, 1.22–5.22; p = 0.012 for individuals with post-ICS TB, 1.28 95%CI, 0.73–2.26; p = 0.389 for post-ICS pneumonia, 2.3195%CI, 0.84–6.38; p = 0.105 for post-ICS pneumonia+TB, 1.08 95%CI, 0.57–2.03; p = 0.815 for TB, 0.99 95%CI, 0.63–1.55; p = 0.970 for pneumonia, and 0.32 95%CI, 0.05–2.32; p = 0.261 for pneumonia+ TB, respectively.

Conclusions

Post-ICS TB increased lung cancer risk in patients with asthma. Because of the high mortality associated with lung cancer, screening tests are recommended for patients with post-ICS TB.



Author: Zhi-Hong Jian , Jing-Yang Huang , Frank Cheau-Feng Lin, Oswald Ndi Nfor, Kai-Ming Jhang, Wen-Yuan Ku, Chien-Chang Ho, Chia-Chi Lu

Source: http://plos.srce.hr/



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