Evaluating Prostate Cancer Using Fractional Tissue Composition of Radical Prostatectomy Specimens and Pre-Operative Diffusional Kurtosis Magnetic Resonance ImagingReportar como inadecuado




Evaluating Prostate Cancer Using Fractional Tissue Composition of Radical Prostatectomy Specimens and Pre-Operative Diffusional Kurtosis Magnetic Resonance Imaging - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

Evaluating tissue heterogeneity using non-invasive imaging could potentially improve prostate cancer assessment and treatment.

Methods

20 patients with intermediate-high-risk prostate cancer underwent diffusion kurtosis imaging, including calculation of apparent diffusion Dapp and kurtosis Kapp, prior to radical prostatectomy. Whole-mount tissue composition was quantified into: cellularity, luminal space, and fibromuscular stroma. Peripheral zone tumors were subdivided according to Gleason score.

Results

Peripheral zone tumors had increased cellularity p<0.0001, decreased fibromuscular stroma p<0.05 and decreased luminal space p<0.0001. Gleason score ≥4+3 tumors had significantly increased cellularity and decreased fibromuscular stroma compared to Gleason score ≤3+4 p<0.05. In tumors, there was a significant positive correlation between median Kapp and cellularity ρ = 0.50; p<0.05, and a negative correlation with fibromuscular stroma ρ = -0.45; p<0.05. In normal tissue, median Dapp had a significant positive correlation with luminal space ρ = 0.65; p<0.05 and a negative correlation with cellularity ρ = -0.49; p<0.05. Median Kapp and Dapp varied significantly between tumor and normal tissue p<0.0001, but only median Kapp was significantly different between Gleason score ≥4+3 and ≤3+4 p<0.05.

Conclusions

Peripheral zone tumors have increased cellular heterogeneity which is reflected in mean Kapp, while normal prostate has a more homogeneous luminal space and cellularity better represented by Dapp.



Autor: Edward M. Lawrence , Anne Y. Warren, Andrew N. Priest, Tristan Barrett, Debra A. Goldman, Andrew B. Gill, Vincent J. Gnanapragasa

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados