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Abstract: Complex networks provide us a new view for investigation of immune systems.In this paper we collect data through STRING database and present a model withcooperation network theory. The cytokine-protein network model we consider isconstituted by two kinds of nodes, one is immune cytokine types which can actas acts, other one is protein type which can act as actors. From act degreedistribution that can be well described by typical SPL -shifted power lawfunctions, we find thatHRAS.TNFRSF13C.S100A8.S100A1.MAPK8.S100A7.LIF.CCL4.CXCL13 are highlycollaborated with other proteins. It reveals that these mediators are importantin cytokine-protein network to regulate immune activity. Dyad act degreedistribution is another important property to generalized collaborationnetwork. Dyad is two proteins and they appear in one cytokine collaborationrelationship. The dyad act degree distribution can be well described by typicalSPL functions. The length of the average shortest path is 1.29. These resultsshow that this model could describe the cytokine-protein collaborationpreferably



Autor: Sheng-Rong Zou, Ta Zhou, Yu-Jing Peng, Zhong-Wei Guo, Chang-gui Gu, Da-Ren He

Fuente: https://arxiv.org/







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