Beneficial haemodynamic effect of indomethacin during endotoxin shock in anaesthetized pigsputative involvement of nitric oxideReportar como inadecuado




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Mediators of Inflammation - Volume 4 1995, Issue 2, Pages 117-123



Department of Pharmacology, Cardiovascular Research Institute ‘COEUR’, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, Postbox 1738, Rotterdam 3000 DR, The Netherlands

Department of Traumatology, Semmelweis University of Medical Sciences, Péterfy Hospital, P.O. Box 76, Budapest 1441, Hungary

Department of Pharmacology, University of Sydney, Australia



Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Endotoxin shock was induced in 31 anaesthetized pigs by infusion of 5 μg-kg of Escbeicbia coli endotoxin LPS over 60 min into the superior mesenteric artery. Fifteen of these pigs died within 30 min of the start of LPS infusion whereas the remaining 16 survived the experimental period of 2 h. In a group of nine pigs indomethacin 2 mg-kg, i.v.was inected 20–25 rain after the start of LPS infusion at which time mean arterial blood pressure MABP had decreased below 40 mmHg indicating imminent death. Indomethacin immediately reversed the hypotension. In another group of five pigs, N

-nitro L-arginine-methyl ester L-NAME, 1 and 3 mg-kgwas iniected 10 and 5 min, respectively, before the expected death without any beneficial effect on the hypotension. Three rain after the last dose of L-NAME, indomethacin 2 mg-kg, i.v. was iniected. In three animals the hypotension was reserved by indomethacin, although this beneficial effect was delayed in comparison with the LP-Streated group not receiving L-NAME. Four pigs were pretreated with L-NAME, 3 mg-kg, i.v., 10 min prior to LPS infusion. All pretreated animals tended to die within 30 min of the start of the LPS infusion. Five rain before the expected death 20–25 rain after the start of LPS infusion indomethacin 2 mg-kg was inected. In three of these animals indomethacin reversed hypotenston and prevented death. Interestingly, this rise in the MABP developed very slowly. These results suggest that the beneficial effect of indomethacin in endotoxin shock might be related partially to interference with nitric oxide, which is not the only factor determining blood pressure levels during endotoxic shock.





Autor: T. Mózes, E. M. van Gelderen, E. J. Mylecharane, and P. R. Saxena

Fuente: https://www.hindawi.com/



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