All Components of Metabolic Syndrome Are Associated with Microalbuminuria in a Chinese PopulationReportar como inadecuado




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Background and Aim

Albuminuria is a well-known predictor of poor renal and cardiovascular outcomes and associated with increased risk of all-cause mortality. The study aimed to evaluate the associations between metabolic characteristics and the presence of albuminuria.

Methods

This cross-sectional study included 18,384 adult Chinese who participated in health examinations during 2013–2014. Differences in clinical characteristics were compared for microalbuminuria MAU and albuminuria, and between genders. Potential risk factors associated with the risk of developing MAU and albuminuria were analyzed using univariate logistic regression. Multiple logistic regression was applied to further identify the independent associations between different levels of risk factors and the presence of MAU and albuminuria. The area under the ROC curve AUC was used to determine the discriminatory ability of metabolic risk factors in detecting albuminuria.

Results

There were significant gender differences in clinical characteristics according to albuminuria status. Risk for the presence of albuminuria was significantly associated with age, male gender, waist circumference WC, waist-to-height ratio WHtR, hypertension, fasting plasma glucose FPG, and triglycerides to high-density lipoprotein cholesterol ratio TG-HDL-C in univariate logistic regression. Multiple logistic regression analysis indicated that the factors significantly associated with the presence of MAU were WC > 90cm, WHtR at 0.6–0.7, hypertension, FPG > 6.1 mmole-L, and TG-HDL-C ratio > 1.6. The optimal cutoffs for risk factors of metabolic syndrome MetS to predict albuminuria in males and females were: WC, 90.8 vs. 80.0 cm; WHtR, 0.53 vs. 0.52; MAP, 97.9 vs. 91.9 mmHg; FPG, 5.40 vs. 5.28 mmole-L; and TG-HDL-C, 1.13 vs. 1.08.

Conclusion

MetS and all its components were associated with the presence of MAU in a health check-up population in China. Gender specific and optimal cutoffs for MetS components associated with the presence of MAU were determined.



Autor: Yi-Yen Lee, Chih-Kai Yang, Yi-Ming Weng, Chung-Hsun Chuang, Wei Yu, Jih-Chang Chen, Wen-Cheng Li

Fuente: http://plos.srce.hr/



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