Survey of Intraocular Antibiotics Prophylaxis Practice after Open Globe Injury in ChinaReport as inadecuate

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To elucidate the Chinese practice of intraocular antibiotics administration for prophylaxis after open globe injury.


A cross-sectional questionnaire survey was performed online by scanning a Quickmark QR code with smartphones at the 20th Chinese National Conference of Ocular Trauma in November 2014.


A total of 153 30.6% of all participators at the conference responded. Of the respondents, 20.9% were routinely administered with prophylactic intraocular injection of antibiotics at the conclusion of the primary eye repair, and 56.9% were used only in cases with high risk of endophthalmitis development. The intraocular route of delivery was mainly included with intracameral injection 47.9% and intravitreal injection 42.0%. Cephalosporins 53.8% and vancomycin 42.0% were the main choices of antibiotic agents, followed by fluoroquinolones 24.3%, and aminoglycosides 13.4%. Only 21.9% preferred a combination of two or more two drugs routinely. In addition, significantly more respondents from the referral eye hospital 92.7% replied using intraocular antibiotics injection for prophylaxis compared to those respondents from the primary hospital 69.4% p = 0.001, Fisher’s exact test.


Intraocular antibiotics injection for post-traumatic endophthalmitis prophylaxis is widely used in China. However, the choice of antibiotic agents and the intraocular route of delivery vary. A well-designed clinical trial is needed to establish a standardized protocol of intraocular antibiotics administration for post-traumatic endophthalmitis prophylaxis.

Author: Bingsheng Lou , Lixia Lin , Junlian Tan, Yao Yang, Zhaohui Yuan, Xiaofeng Lin



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