Age, Gender and Load-Related Influences on Left Ventricular Geometric Remodeling, Systolic Mid-Wall Function, and NT-ProBNP in Asymptomatic Asian PopulationReportar como inadecuado




Age, Gender and Load-Related Influences on Left Ventricular Geometric Remodeling, Systolic Mid-Wall Function, and NT-ProBNP in Asymptomatic Asian Population - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

Advanced age is associated with left ventricle LV remodeling and impaired cardiac function that may increase the risk of heart failure. Even so, studies regarding age-related cardiac remodeling in a large, asymptomatic Asian population remain limited.

Materials and Methods

We studied 8,410 asymptomatic participants 49.7 ±11.7 y, 38.9% women in a health evaluation cohort 2004–2012 at a tertiary center in Northern Taiwan. We analyzed age-related alterations for all echocardiography-derived cardiac structures-functions and the associations with circulating N-terminal prohormone of brain natriuretic peptide NT-proBNP. We also explored sex-related differences in these measures.

Results

In our cohort of 8,410 participants, advanced age was associated with greater LV wall thickness, larger LV total mass +5.08 g-decade, and greater LV mass index 4.41 g-m2-decade, as well as increased serum NT-proBNP level +18.89 pg-mL-decade. An accompanying reduction of stress-corrected midwall fractional shortening –0.1%-decade with aging was apparent in women after multi-variate adjustment –0.09%-decade, p = 0.001. Furthermore, women demonstrated greater overall increase in LV wall thickness, LV mass index, and NT-proBNP compared to men p for interaction: <0.001. All blood pressure components, including systolic, diastolic, and pulse pressures were independently associated with greater wall thickness and LV mass index after adjustment for confounders all p <0.001. The associations between age and cardiac remodeling or mid-wall functions were further confirmed in a subset of study subjects with repeated follow up by GEE model.

Conclusions

Significant associations of unfavorable LV remodeling and advanced age in our asymptomatic Asian population were observed, along with sex differences. These data may help explain the incidence of some diverse gender-related cardiovascular diseases, especially heart failure.



Autor: Chi Chen, Kuo-Tzu Sung, Shou-Chuan Shih, Chuan-Chuan Liu, Jen-Yuan Kuo, Charles Jia-Yin Hou, Chung-Lieh Hung , Hung-I Yeh

Fuente: http://plos.srce.hr/



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