Cutaneous Melanoma with Brain Metastasis: Report of 193 Patients with New ObservationsReportar como inadecuado

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Brain metastasis is a common endpoint in patients suffering from malignant melanoma. However, little is known about factors that predispose to brain metastases.


We performed a retrospective clinical and pathological investigation of melanoma patients with brain metastases in order to better characterise this patient population.


193 melanoma patients with brain metastasis histologically diagnosed between 1990 and 2015 at the University Hospital Zurich were retrospectively identified and further specified for sex, age at diagnosis and detection of brain metastasis, and localisation. In addition, data were extracted regarding the subtype of primary melanoma, Breslow tumour thickness, Clark Level, mutation status, extent of metastatic spread and history of a second melanoma.


We found a significant male predominance n = 126-193; 65%; p < 0.001. Breslow tumour thickness showed a wide range from 0.2 to 12.0 mm n = 99; median 2.3 mm. 14 of 101 melanomas 14% were classified as T1, thereof 11 79% were found in men. In 32 of 193 patients 17%, the primary melanoma was unknown.


Of special interest in our series is the high incidence of male predominance 79% in cases of thin metastasing melanoma 14%, implicating genetic or epigenetic hormonal gender differences underlying tumour progression. Additionally, the high percentage of unknown primary melanoma 17%, at least partly representing completely regressed melanomas, indicates the importance of immune surveillance in melanoma progression.

Autor: Alenka Gugger, Raymond L. Barnhill, Burkhardt Seifert, Silvia Dehler, Holger Moch, Claire Lugassy, Ewerton Marques-Maggio, Elisab



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