Histologic Assessment of Intratumoral Lymphoplasmacytic Infiltration Is Useful in Predicting Prognosis of Patients with Hepatocellular CarcinomaReportar como inadecuado




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In the present study, we investigated the clinicopathologic significance of intratumoral lymphoplasmacytic infiltration in a large cohort of patients with solitary hepatocellular carcinoma HCC. Based on examination of hematoxylin and eosin-stained sections, significant infiltration was defined as dense lymphoplasmacytic infiltration, either multifocal or diffuse, in 2 or more fields under low-power magnification. Of 544 cases, 216 39.7% were positive for significant infiltration HCC-LI group, while 328 60.3% were negative HCC-NLI group. There were no significant between-group differences in patient age, sex, or background etiology. The lower incidence of Child-Pugh stage B P = 0.001 and lower level of indocyanine green retention rate at 15 minutes P < 0.001 in the HCC-LI group indicated better liver function in this group. Histologically, tumors were significantly smaller in size in the HCC-LI group than in the HCC-NLI group P < 0.001. In addition, prominent neutrophilic infiltration, interstitial fibrosis and tumor steatosis were significantly more frequent P < 0.001 in the HCC-LI group, while tumor necrosis was significantly less frequent P = 0.008. Kaplan-Meier analyses revealed that overall and recurrence-free survival were significantly better in the HCC-LI group P < 0.001. Multivariate Cox regression analysis showed that intratumoral lymphoplasmacytic infiltration was independently prognostic of both overall and recurrence-free survival P < 0.001, with absence of infiltration showing high Cox-hazard ratios for poor prognosis. In conclusion, intratumoral lymphoplasmacytic infiltration, as determined by assessment of hematoxylin and eosin-stained slides, was significantly associated with the clinical and pathologic features of HCC and has profound prognostic importance.



Autor: Akimasa Hayashi, Junji Shibahara , Kento Misumi, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Masashi Fu

Fuente: http://plos.srce.hr/



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